SIMVASTATIN-what are these pills and what are they taking

SIMVASTATIN-what are these pills and what are they taking?

SIMVASTATIN-what are these pills and what are they taking?

  1. is used in cardiovascular diseases (primary hypercholesterolemia, ischemic heart disease for the prevention of myocardial infarction, for the slowing down of coronary atherosclerosis
  2. Statins. Take with high cholesterol in the blood.
  3. Into the googol!
  4. When administered orally, it is hydrolyzed to form an active metabolite that inhibits 3-hydroxy # 8722, 3-methyl-glutaryl-CoA reductase (catalyzes the limiting stage of cholesterol synthesis). Reduces both increased and normal levels of cholesterol, the concentration of LDL and VLDL. As a result, the ratio of HDL to LDL is increased and cholesterol / HDL is reduced. Increases the level of HDL and reduces the concentration of triglycerides. In the hereditary absence of LDL receptors (homozygous familial hypercholesterolemia), simvastatin is ineffective. A reliable clinical result is obtained through 2 weeks after the start of treatment, the maximum through 46 weeks. Long-term use of 2040 mg / day improves the survival of patients with hypercholesterolemia and IHD, reduces the progression of atherosclerotic lesions of the coronary arteries. Active with ineffectiveness of diet therapy and other non-pharmacological methods of treatment.

    After oral administration, the concentration of simvastatin and its metabolites (formed mainly in the liver) reaches a maximum through 4 h and decreases by 90% in 12 h. Both simvastatin and its biotransformation products in plasma at 95% are associated with proteins. Hypercholesterolemic activity is retained by 6-hydroxy-, 6-hydroxymethyl- and 6-exomethylene derivatives. It is excreted as metabolites with bile (60%) and urine (13%).
    Application of the substance Simvastatin

    Hypercholesterolemia in the absence of the effect of diet, combined hypercholesterolemia and triglyceridemia, IHD, prevention of myocardial infarction and stroke, atherosclerosis.
    Противопоказания

    Hypersensitivity, acute violations of the liver, severe renal failure, pregnancy, breast-feeding, children's age.
    Application in pregnancy and lactation

    FDA Action Category X.
    Side effects of the substance Simvastatin

    Dyspeptic phenomena, diarrhea, flatulence, nausea, exacerbation of pancreatitis and hepatitis, increased levels of transaminases, CNS disorders (headache, paresthesia, seizures), myalgia, asthenia, myopathy, rhabdomyolysis, photosensitivity, allergic reactions (vasculitis, urticaria, arthralgia, thrombocytopenia, eosinophilia, angioedema, symptoms similar to lupus erythematosus).
    Interaction

    Immunodepressive therapy, high doses of nicotinic acid, antifungal drugs azole derivatives (ketoconazole, itraconazole) increase the risk of myopathy and rhabdomyolysis. Strengthens the effects of indirect anticoagulants, hepatotoxicity of alcohol and drugs that negatively affect the liver.
    Dosing and Administration

    Inside: at the beginning of the course, once a dose of 510 mg / day, if necessary up to 40 mg per day, depending on the content of cholesterol and lipoproteins in the blood. With IHD, the initial dose of 20 mg / day is single.

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  • SIMVASTATIN-what are these pills and what are they taking SIMVASTATIN-what are these pills and what are they taking SIMVASTATIN-what are these pills and what are they taking SIMVASTATIN-what are these pills and what are they taking SIMVASTATIN-what are these pills and what are they taking SIMVASTATIN-what are these pills and what are they taking SIMVASTATIN-what are these pills and what are they taking SIMVASTATIN-what are these pills and what are they taking SIMVASTATIN-what are these pills and what are they taking SIMVASTATIN-what are these pills and what are they taking